Researchers at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) have developed a one-micrometer-resolution version of the intravascular imaging technology optical coherence tomography (OCT) that can reveal cellular and subcellular features of coronary artery disease. In a Nature Medicine paper receiving advance online publication, the investigators describe how microOCT — which provides 10 times greater resolution than standard OCT — was able to show individual arterial and inflammatory cells, including features that may identify vulnerable plaques, within coronary artery samples.“MicroOCT has the contrast and resolution required to investigate the cellular and subcellular components underlying coronary atherosclerosis, the disease that precipitates heart attack,” says Harvard Medical School Professor Gary Tearney of the Wellman Center and the MGH Pathology Department, who led the study. “This high level of performance opens up the future possibility of observing these microscopic features in human patients, which has implications for improving the understanding, diagnosis, and therapeutic monitoring of coronary artery disease.”A catheter-based technology, OCT uses reflected near-infrared light to create detailed images of the internal surfaces of blood vessels. Although the technology is already being used to identify arterial plaques that are likely to rupture, standard OCT can clearly image only structures larger than 10 micrometers (millionths of a meter). Using new types of lenses and advanced imaging components, microOCT is able to image structures as small as one micrometer, revealing in intact tissue the detailed information provided by the prepared tissue slides of traditional pathology much faster and in 3-D.The researchers describe how using microOCT to study human and animal coronary artery tissue revealed detailed images of:endothelial cells that line coronary arteriesinflammatory cells that contribute to the formation of coronary plaquessmooth muscle cells that produce collagen in response to inflammationfibrin proteins and platelets that are involved in the formation of clotsMicroOCT also produced detailed images of stents placed within coronary arteries, clearly distinguishing bare-metal stents from those covered with a drug-releasing polymer and revealing defects in the polymer coating.“When we are able to implement microOCT in humans — probably in three to five years — the 10 times greater resolution will allow us to observe cells in the coronary arteries of living patients,” says Tearney. “The ability to track and follow cells in three dimensions could help us prove or disprove many theories about coronary artery disease and better understand how clots form on a microscopic level. Improved definitions of high-risk plaques will lead to greater accuracy in identifying those that may go on to rupture and block the coronary artery, and the ability to monitor healing around implanted devices like stents could reduce the number of patients who must be on anticlotting medications, which are expensive and have side effects.”Linbo Liu of the Wellman Center developed the microOCT system and is lead author of the Nature Medicine paper. Additional co-authors are Joseph Gardecki, Seemantini Nadkarni, Jimmy Toussaint, Yukako Yagi, and Brett Bouma, all of the Wellman Center for Photomedicine at MGH. The study was supported by grants from the National Institutes of Health and the Cystic Fibrosis Foundation. Massachusetts General Hospital has filed patent applications on the microOCT technology.
70 Serenity Boulevard, Helensvale. Video Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 1:50Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -1:50 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD540p540p360p360p180p180pAutoA, selectedAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenDifferences between building in new or established estates01:50 70 Serenity Boulevard, Helensvale.More from news02:37International architect Desmond Brooks selling luxury beach villa13 hours ago02:37Gold Coast property: Sovereign Islands mega mansion hits market with $16m price tag2 days ago“We just really liked the feel of dark rendered walls with timber and concrete,” Mr Van Kersen said.MORE NEWS: Live on the Edge 70 Serenity Boulevard, Helensvale. The couple built the house themselves through Mr Van Kersen’s building company, Van Kersen Homes. They have lived in it for the past year.“The design process was actually really quick because we knew exactly what we wanted then it only took us about six months to build,” Mrs Van Kersen said. 70 Serenity Boulevard, Helensvale.IT is the type of house that stands out in a crowd, and not just because it has an unusually dark exterior.Feature lighting, natural materials including travertine stone, timber and polished concrete as well as wide windows give the two-storey Helensvale property a sense of elegance.Owners Danielle and Jonathan Van Kersen took an industrial style and blended it with warmer tones when they designed the four-bedroom house on Serenity Boulevard. MORE NEWS: Fancy a NRL halfback for a landlord? 70 Serenity Boulevard, Helensvale. 70 Serenity Boulevard, Helensvale.The waterfront home has a main bedroom with ensuite on each level, a built-in bar, alfresco dining area and pool.Mrs Van Kersen said they loved the home’s open floorplan, especially that they could further open the living area out onto the alfresco area.“In the afternoons, we get an absolutely wicked sunset,” she said. While reluctant to sell the house, they want to pursue another project. 70 Serenity Boulevard, Helensvale.