UK stem cell stroke trial passes first safety test

first_imgStem cells may be able to repair the damaged areas of the brainThe world’s first clinical trial of brain stem cells to treat strokes is set to move to its next phase. An independent assessment of the first three patients to have had stem cells injected into their brain at Glasgow’s Southern General Hospital has concluded it has had no adverse effect.The assessment paves the way for the therapy to be tested on more patients to find a new treatment for stroke. The hope is that the stem cells will help to repair damaged brain tissue.The trial is being led by Prof Keith Muir of Glasgow University. He told BBC News that he was pleased with the results so far.“We need to be assured of safety before we can progress to trying to test the effects of this therapy. Because this is the first time this type of cell therapy has been used in humans, it’s vitally important that we determine that it’s safe to proceed – so at the present time we have the clearance to proceed to the next higher dose of cells.”An elderly man was the first person in the world to receive this treatment last year. Since then it has been tried out on two more patients.Global trialsThe patients have received very low doses of stem cells in trials designed to test the safety of the procedure.Over the next year, up to nine more patients will be given progressively higher doses – again primarily to assess safety – but doctors will also be using this clinical trial to assess the best ways of measuring the effectiveness of the treatment in subsequent larger trials, which would not begin for at least 18 months.Critics object as brain cells from a foetus were originally used to create the cell treatment. Michael Hunt, Chief Executive Officer of the company that produced the stem cells, Renuron, said that the technology used to grow the cells is such that no further foetal tissue will be required. There are a growing number of well-regulated clinical trials of stem cell treatments now under way in various parts of the world, including one which also began last year by the US firm Geron to develop a treatment for paralysis. The development of stem cell treatments is still at an early stage and it is likely to be many years before these treatments become widely available. According to Mr Hunt: “The earliest a treatment could be widely available if everything goes very well is five years. It is very much a case of so far, so good. It is still at a very early stage but we draw great comfort from these results.”Strokes kill about 67,000 people in the UK every year, according to the Stroke Association.The charity says it is the third most common cause of death in England and Wales after heart disease and cancer.By Pallab GhoshScience correspondent, BBC News Share Sharing is caring! Share Sharecenter_img 11 Views   no discussions Tweet HealthLifestyle UK stem cell stroke trial passes first safety test by: – September 1, 2011last_img read more

Attorney: Epstein Victims Want Notice of Estate Plans

first_imgEven though Jeffrey Epstein’s alleged victims were not aware that he made a deal with prosecutors to avoid a long prison sentence a decade ago, an attorney who is representing some of those individuals just filed court papers that prevent Epstein’s estate from being divided up without the lawyer’s knowledge.Fort Lauderdale attorney Bradley Edwards submitted the paperwork on Wednesday, although legal proceedings have not yet been filed over Epstein’s fortune.The financier and former Palm Beach resident was not married and did not have children, although he is survived by a brother, as well as a niece and nephew.Lisa Bloom, a Los Angeles-based attorney representing another two victims, has also filed a request asking for Epstein’s assets to be frozen.In a process called a “caveat,” Florida law allows interested parties who want to prevent an estate from being administered without their knowledge to file papers requiring that they be notified when a probate case is actually filed. A judge may not appoint someone to handle the estate until that notification is made.Epstein reportedly hanged himself in his cell at the Manhattan Correctional Center last Saturday morning.Although his death ends the criminal case against him, legal proceedings over his fortune, estimated to be at least $500 million, are expected to continue for some time.Epstein did not declare his Palm Beach home, which he had owned since 1990, as his homestead. Rather, court papers show that he claimed his legal residence was one of two islands that he owned in the U.S. Virgin Islands. He also owned a townhouse in Manhattan that is valued at $77 million, in addition to at least one aircraft.last_img read more

City anticipates tough choices in Flutter’s pursuit of Stars

first_img StumbleUpon Canada’s sports betting hearings threatened by Trudeau’s ’emergency recess’  August 24, 2020 Related Articles Tabcorp double burdened by covid and group impairment charges August 19, 2020 Submit Flutter moves to refine merger benefits against 2020 trading realities August 27, 2020 Share Share City analysts are pondering how Flutter Entertainment will sooth competition concerns across multiple markets, attached to its bold merger pursuit with digital rival The Stars Group Inc.Since the merger was propositioned on 2 October, Flutter CEO Peter Jackson and corporate governance have emphasised confidence in clearing all regulatory hurdles to deliver a £10 billion online gambling powerhouse.The stakes are high for Jackson and co, as the Flutter-Stars combination will lead US wagering partnerships with Fox Sports, Fastball Holdings and Boyd Interactive – all dependent on the deal being completed.Nevertheless, city analysts believe that Flutter governance will face tough decisions if they are to secure regulatory harmony on a Stars merger if US ambitions are to be delivered.This weekend, Canadian investment bank Canaccord Genuity issued an industry note to the Sunday Times detailing that it viewed a sale of flagship brand Paddy Power as the ‘most logical decision’ for Flutter to undertake.A Flutter-Stars combination would create an entity with a 40% share of the UK online gambling marketplace, servicing three of the UK’s top seven most popular online bookmakers in Paddy Power, Betfair and Sky Bet.In its note, Canaccord details that the above conditions will likely lead to UK CMA ‘concerns over consumer choice’ in online betting.A Paddy Power break-up would be viewed as a controversial move, as Peter Jackson had previously underlined ‘returning the bookmaker to growth’ as core remit of the executive taking leadership of the FTSE firm in 2018.Revitalising Paddy Power, Flutter has spent significant money and resources upgrading the bookmaker’s operating systems, all-round product proposition and revamping its loyalty programme wholesale.In addition, Paddy Power’s ambitions have been supported by a number of high coverage UK advertising campaigns, as Peter Jackson moves to re-establish Flutter’s legacy brand as a leading mass-market bookmaker.Elsewhere, analysts anticipate a market probe by either Australian Competition Tribunal (ACT) or the Australian Competition & Consumer Commission (ACCC) examining Flutter-Stars potential impacts on Australian sports betting.In its acquisition note, Flutter governance stated that there should be no regulatory concerns in Australia as the company would be against TAB Holdings as the market leader.Nevertheless, Flutter-Stars would control Australian online betting leader Sportsbet.com.au and BetEasy, a sportsbook brand formed by the Stars Group combining CrownBet and William Hill Australia for AUS $600 million (€480 million), which may see AUS competitors demand an ACT/ACCC watchdog review.At present, Flutter governance maintains its schedule of completing the transaction by Q2-to-Q3 2020, an ambitious target for the merger’s stakeholders.last_img read more