August 12 2009 This is the fourth installment in

first_imgAugust 12, 2009 This is the fourth installment in a series of reports with the most recent 3D renderings of “SOLARE The Lean Linear City”. Excerpts from BEYOND GRIDLOCK Paolo Soleri’s Lean Linear City by Tomiaki Tamura, Cosanti Foundation, August 2009. [Waste Management] SOLARE’s urban structures certainly make waste material collection more efficient. The linear transportation system also provides easier access to processing and recycling locations, and to waste disposal sites. [3D rendering: YoungSoo Kim & text: Tomiaki Tamura] The biologically processed (composting) materials fill the landscaping and garden soil enrichment needs. The energy recovery system in forms of solid, liquid and gaseous materials can also be adopted. [3D rendering: YoungSoo Kim & text: Tomiaki Tamura] Perhaps the largest contribution to waste management in SOLARE is the reduction in the absolute amount of material consumption; redefining the “quality of life” by giving its residents pedestrian access to many amenities, so that each resident does not have to own everything (but can share), therefore creating an environment in which less materials are needed. [3D rendering: YoungSoo Kim & text: Tomiaki Tamura] [Agriculture/Greenhouse] Sustainable agriculture may be a somewhat elusive concept, especially with the complexity of varied and shifting environmental conditions, and socio-economic needs of the communities that produce and consume the goods involved in the process. [3D rendering: YoungSoo Kim & text: Tomiaki Tamura] However, humanity’s attempt to reduce the ecological footprint that supports our lifestyle necessitates bringing agricultural activities much closer to the habitat where the consumption occurs. SOLARE explores urban agriculture in the adjacent open field (close proximity to the human habitat) and vertical farm built into the structure where applicable. Another unique feature of SOLARE is the terraced greenhouse unit (Energy Apron) intended to extend the growing season and provide diversified horticulture and floriculture practices within its stratified micro-climatic conditions. This glazed productive environment substantially reduces the amount of water usage, while diverting excess heat to upper structures for space heating when needed. This report continues on 8/14/2009. [3D rendering: YoungSoo Kim & text: Tomiaki Tamura]last_img read more

Turner in partnership with Warner Bros has annou

first_imgTurner, in partnership with Warner Bros, has announced plans to roll out its US subscription video-on-demand service Filmstruck internationally, starting in the UK.Turner International’s Digital Ventures and Innovation (DV&I) Group and Warner Bros. Digital Networks (WBDN) have agreed a joint venture to launch the film streaming service across multiple territories in the next two years.The service will draw primarily on the Warner Bros. library and the Criterion Collection library, as well as other global and local content partners, and will launch in the UK in association with cinema brand Curzon.The UK version of the offering will be called FilmStruck Curzon, will feature a branded Curzon area within the service curated in collaboration with Curzon, and is due to go live in the coming weeks.“We’re thrilled to take this significant step together as a joint venture with Warner Bros. Digital Networks, after many years of growing collaboration across various other projects with Warner Bros. as a whole,” said Aksel van der Wal, executive vice president, Turner DV&I.“FilmStruck helps us realise a shared vision for what we see as a clear gap in the market for film lovers around the world. We’re also delighted to be working with a partner of Curzon’s heritage and prestige.”Craig Hunegs, president, business and strategy, Warner Bros. Television Group and president, Warner Bros. Digital Networks, said: “International film fans now have a new home for a wide and diverse range of movies including some of Warner Bros.’ most iconic titles.”Philip Mordecai, director of digital ventures, Curzon, added: “It is tremendously exciting to see Filmstruck Curzon launching in UK. We look forward to collaborating on the curation of the site and introducing this excellent service to our customers across the Curzon group.”With the launch, Turner International will now offer three international SVOD brands, the other two being sports service EI Plus in Brazil, and recently launched kids and family brand Toonix in the Nordics.Turner first launched Filmstruck in the US in October 2016 with a focus on arthouse, indie, foreign and cult films. The service was developed and managed by Turner Classic Movies (TCM) in collaboration with the Criterion Collection and is available online and as an app across a number of streaming platforms.Curzon’s involvement in the project comes after it launched a membership SVOD service called Curzon12 last year. This allows Curzon cinema members to stream 12 ‘essential films’ for free at home each month by entering their Curzon membership number.last_img read more

Takeda announces positive Phase 3 ALTA1L data in firstline therapy for advanced

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 22 2018Takeda Pharmaceutical Company Limited today announced that intracranial efficacy data from the Phase 3 ALTA-1L (ALK in Lung Cancer Trial of BrigAtinib in 1st Line) trial showed improved intracranial progression-free survival (PFS) and intracranial objective response rate (ORR) with ALUNBRIG (brigatinib) compared to crizotinib among anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC) patients. Data for these secondary endpoints will be presented in a poster discussion at the European Society for Medical Oncology (ESMO) 2018 Congress on Friday, October 19 at 2:00 p.m. CET in Munich, Germany. These results further support ALUNBRIG as a potential treatment for adults with ALK+ locally advanced or metastatic NSCLC who had not received a prior ALK inhibitor. ALUNBRIG is currently not approved as first-line therapy for advanced ALK+ NSCLC.”ALK+ NSCLC often spreads to the brain, so having options that can clearly demonstrate efficacy both in the brain and systemically is important for physicians and their patients,” said Sanjay Popat, PhD, FRCP, Medical Oncologist, Royal Marsden Hospital. “The ALTA-1L trial showed that treatment with brigatinib significantly delayed progression of disease in the brain compared to crizotinib, and we look forward to sharing the clinical evidence with the medical community at ESMO.”In the first interim analysis of the ALTA-1L trial, intracranial PFS was significantly improved with ALUNBRIG compared to crizotinib in the Intention to Treat population (ITT) (Hazard ratio [HR]: 0.42, 95% confidence interval [CI]: 0.24−0.70; log-rank P=0.0006) and the population with baseline brain metastases (HR: 0.27, 95% CI: 0.13−0.54; log-rank P<0.0001). Among patients with brain metastases at baseline, ALUNBRIG reduced the risk of progression in the brain or death by 73 percent. Intracranial PFS in patients without brain metastases at baseline is not yet mature as of this first interim analysis.Treatment with ALUNBRIG also demonstrated an improved intracranial ORR compared to crizotinib. For patients with measurable brain metastases at baseline, 78 percent achieved confirmed intracranial OR in the ALUNBRIG arm versus 29 percent in the crizotinib arm. For patients with non-measurable brain metastases at baseline, 67 percent achieved confirmed intracranial OR in the ALUNBRIG arm versus 17 percent in the crizotinib arm.Related StoriesSugary drinks linked to cancer finds studyStudy reveals link between inflammatory diet and colorectal cancer riskUsing machine learning algorithm to accurately diagnose breast cancerIn addition, ALUNBRIG significantly delayed both central nervous system (CNS) progression (without prior systemic progression) and systemic progression (without prior CNS progression) compared to crizotinib. Baseline factors related to the CNS, such as the proportion of patients with baseline brain metastases, mean number of brain metastases, and prior brain radiotherapy, including type, were balanced among patients in the two study arms. The safety profile associated with ALUNBRIG in the ALTA-1L trial was generally consistent with the existing U.S. prescribing information."CNS disease presents a significant burden for patients with ALK+ NSCLC," said David Kerstein, MD, Global Clinical Lead for Brigatinib and Lung Cancer Clinical Portfolio Strategy Lead, Takeda. "These additional intracranial efficacy results from the ALTA-1L trial build upon activity previously reported with ALUNBRIG in patients with brain metastases in the post-crizotinib setting and demonstrate Takeda's dedication to research that aims to improve outcomes for those living with this serious disease."These data build on results recently presented during the Presidential Symposium at the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer (WCLC), which showed that treatment with ALUNBRIG resulted in superior PFS compared to crizotinib as assessed by a blinded independent review committee, corresponding to a 51 percent reduction in the risk of disease progression or death (HR: 0.49, 95% CI: 0.33−0.74]; log-rank P=0.0007).Grade 3 to 5 treatment-emergent adverse events occurred in 61% of the patients in the brigatinib arm and 55% of the patients in the crizotinib arm. Most common grade 3 or greater treatment-emergent adverse events for brigatinib were increased blood creatine phosphokinase (16%), increased lipase (13%), hypertension (10%), and increased amylase (5%); and for crizotinib were increased alanine aminotransferase (9%), increased aspartate aminotransferase (6%), and increased lipase (5%). Source:https://www.takeda.com/newsroom/newsreleases/2018/takeda-to-present-results-from-phase-3-alta-1l-trial-highlighting-intracranial-efficacy-of-alunbrig-brigatinib-versus-crizotinib-in-first-line-advanced-alk-non-small-cell-lung-cancer/last_img read more

Chicago airport plan is one of many Musk dream projects

first_imgThis undated artist’s rendering provided by The Boring Company, shows an electric public transportation vehicle that is part of a proposed high-speed underground transportation system that will transport passengers from downtown Chicago to O’Hare International Airport. A spokesman for Chicago Mayor Rahm Emanuel confirmed Wednesday, June 13, 2018, that The Boring Company, founded by Tesla CEO Elon Musk has been selected to build the transportation system. (The Boring Company via AP) A newly announced project by billionaire innovator Elon Musk for a tunnel transit system that would carry travelers to and from Chicago O’Hare International Airport at up to 150 mph (241 kph) is just another project on a growing list of Musk dream projects. © 2018 The Associated Press. All rights reserved. Citation: Chicago airport plan is one of many Musk dream projects (2018, June 15) retrieved 18 July 2019 from https://phys.org/news/2018-06-chicago-airport-musk.html Elon Musk says LA-area test tunnel almost complete (Update)center_img Explore further A look at some of the SpaceX and Tesla CEO’s most ambitious projects, where they stand now and some hurdles to their completion:MARS MISSIONSArguably Musk’s boldest or most far-fetched project, depending on who you ask, is one to send manned missions to Mars. He’s even spoken about colonizing the red planet. According to the SpaceX website, the “aspirational goal is to send our first cargo mission to Mars in 2022.” The first unmanned Mars mission would seek to confirm the presence of water and identify other resources that could help sustain human life. And the manned Mars mission? Musk’s goal is for that to happen just two years later, in 2024. By contrast, NASA has spoken about the mid-2030s as a realistic goal for sending humans to Mars.A powerful new rocket capable of making it to Mars is already being developed. The Los Angeles harbor commissioners in April approved a permit for SpaceX to build a facility on port land to manufacture it.Among the unresolved challenges: How to protect humans from radiation on Mars, which lacks the atmosphere of Earth. There are psychological challenges, too. Humans on Mars, especially before a full human colony is established, would have to grapple with a sense of extreme isolation—and boredom.TUNNELINGChicago is one of several cities where Musk has spoken about using tunnel-boring technology developed by his Boring Co. for transportation projects. Among the furthest along is one that would scoot commuters underground on electric sleds called skates to the Los Angeles International Airport. Weeks after tweeting last year that snarling traffic was “driving me nuts,” Musk said work on a tunnel was about to start. Last month, he said a portion of a tunnel was almost finished under an LA suburb and would soon be ready for testing. Among the challenges for any such project is to secure the necessary approval from state and municipal governments. Last year, a suburban city council approved an approximately 2-mile (3.2-kilometer) test tunnel from Musk’s SpaceX rocket plant to a point east of LAX.HYPERLOOPMusk also wants to overhaul the entire U.S. transportation system. He envisions an ultra-high-speed hyperloop system that involves nearly airless tubes that speed special capsules over long distances at up to 750 mph (1,200 kph), using magnetism and solar power. It would carry both people and cargo.It’s an idea many states are taking seriously. Several have said they are conducting feasibility studies, including Colorado, Texas and Missouri. Missouri was looking at whether such a system could be installed to move people between St. Louis and Kansas City in a half-hour’s time.’BETTER’ BRAINSMusk in 2017 announced a new venture called Neuralink, which is developing “ultra-high bandwidth implantable brain-computer interfaces to connect humans and computers,” its website says. Implants could treat neural disorders. Musk has also raised the possibility of artificially intelligent computers posing a threat to humanity in the future, and he says linking brains to computers could put humans’ abilities to process data on par with supercomputers. Linking technology directly to the human body is already happening, including to help deaf people hear. At least some neuroscientists say putting the timetable for actually hooking up brains to computers in terms of several years is overly optimistic. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Boeing 737 Max The FAA wanted a safe plane – but didnt

first_img Provided by The Conversation Global airplane fatalities averaged 840 a year from 2010 to 2018, compared with almost 2,000 in the 1990s. In fact, this decade is on pace to see the fewest casualties since the dawn of jet travel in the 1930s. Yet the March 10 crash of Ethiopian Airlines Flight 302 serves as a stark reminder that despite the significant safety gains in commercial aviation, accidents are still possible. And when they occur, the number of fatalities is often large.What makes the most recent crash particularly concerning is that the airplane design may have played a significant contributing role. Perhaps even worse, there are early indications that regulators at the Federal Aviation Administration – the agency that oversees the development and certification of all U.S. airplanes – may have been more concerned about bringing the Boeing 737 Max to market than about consumer safety.As a result, observers have accused the FAA of being too cozy with Boeing. And transportation officials in both the U.S. and Canada plan to review how the plane got certified to fly by the FAA.As experts on the regulatory process, we see this as a tragic example of what happens when an agency must balance competing goals. The FAA was supposed to protect air travelers and regulate aircraft makers. At the same time, it doesn’t want to make it harder for companies like Boeing to make money in a very competitive global market. Explore further Recent incidents aside, air travel is incredibly safe these days. And a heated rivalry is exactly where Boeing’s current troubles began.Competing in a global marketThe global market for jetliners has been dominated by two major competitors: Boeing and Airbus. Since the 1990s, they’ve been in a bruising battle over market share. Competition has been particularly fierce in the narrow-body or single-aisle aircraft market. This segment historically has made up about two-thirds of deliveries for both Airbus and Boeing. It also holds significant growth potential in the future. Altogether, they have sold and delivered almost 20,000 aircraft from the A320 or 737 families since their respective launches in the 1970s and 1980s.When one company gains even a slight edge by offering a more efficient product, the implications can be massive. This occurred with the highly successful launch of the Airbus 320neo in 2010. The cost savings from reduced fuel consumption proved so significant that even American Airlines, an exclusive Boeing customer at the time, ordered several hundred 320neos. Fuel is the second-highest expense for airlines after labor.Boeing playing catch-upFalling behind its rival, Boeing felt the need to update its 737 family. And it had to do it fast, particularly with regard to fuel efficiency.So Boeing decided to alter the position of the plane’s engines. But doing so changed the plane’s aerodynamics in a way that could cause the plane’s nose to tip upward into a stall, which is what appears to have happened repeatedly before the recent crashes. Boeing sought to solve this engineering problem using an automated correction system known as MCAS. A malfunction of this system may have contributed to the crashes of Ethiopian Airlines Flight 302 and Indonesian Lion Air Flight 610 in October – although investigations are ongoing.Boeing has put out a statement saying that it working with investigators to determine the cause of the crash. The FAA and the Boeing 737 Max 8Even before these incidents, there were concerns that the FAA was delegating too much safety oversight to Boeing itself.The FAA allowed Boeing to handle much of the safety certification process, and Congress supported doing so – though recent events may be prompting lawmakers to change their tune. Reports have suggested that Boeing even excluded FAA technical experts from some of those decisions. In addition, recent analyses suggest that Boeing made several misjudgments when it designed MCAS and hasn’t been fully forthcoming with both the FAA and airlines about how it worked. The airline has also been accused of providing inadequate training for pilots. ‘Regulatory capture’ at the FAA?This has led critics to argue that the FAA has gotten too close to the entity it was supposed to oversee. This situation – when regulatory agencies created to protect the public interest become overly entangled with commercial and special interests – is known as “regulatory capture.” Many see this as corrosive for society. The 2010 Deep Water Horizon oil explosion, the largest marine spill in history, is considered an example of this.Yet, capture is difficult to prove, especially in an era when businesses must work closely with government to ensure that agency officials have the best and latest technical information to develop and issue appropriate regulations. During this process, public regulators are supposed to act in the “public interest.” However, the term is inherently vague and open to a multitude of competing interpretations. Unless it involves outright bribes or other corrupt activities, business influence on regulators fails to amount to criminal conduct.To us, it seems that the FAA was simply caught in an impossible position between the competing goals of protecting consumers and protecting American business interests. In this case, the pendulum may have swung too far to the side of the latter.Unquestionably, we want our airplanes to be safe. And, to be clear, we believe Boeing does as well. Yet we also want American companies to be successful, and regulations are inherently costly and time-consuming for businesses, many of which are competing with companies worldwide.It is not surprising that Boeing was eager to move forward with the 737 Max as fast as possible. Nor is it surprising that the FAA and other regulatory bodies are hesitant to impose excessive burdens on American companies – particularly on one of the nation’s premier exporters. And generally, business interests tend to be much more successful in obtaining their preferred regulatory outcomes than public interest groups. Our own recent work shows that the White House – regardless which party controls it – is more likely to interfere with regulations coming out of more liberal and arguably pro-regulatory agencies. The pendulum keeps swingingThe existence of competing incentives confronting regulatory agencies is nothing new. Public agencies must serve a multitude of goals and objectives and somehow find an appropriate balance.Yet, at times, the balancing act by public agencies may tilt too far in one direction. And unfortunately, when the imbalance occurs at agencies tasked with protecting public safety, the consequences can be exceedingly dire. It seems likely that increased public scrutiny in the wake of the two crashes may force the FAA to take a more aggressive stance on the side of consumer safety in the future. Eventually, however, business interests are likely to begin pushing back, and once again the pendulum will swing the other way. Credit: CC0 Public Domaincenter_img Boeing: 737 MAX certification followed US rules This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Boeing 737 Max: The FAA wanted a safe plane – but didn’t want to hurt America’s biggest exporter either (2019, March 22) retrieved 17 July 2019 from https://phys.org/news/2019-03-boeing-max-faa-safe-plane.html This article is republished from The Conversation under a Creative Commons license. Read the original article.last_img read more

SIT zeroes in on Gauris assassin his outfit

first_imgParashuram Waghmare, the last of the six suspects arrested in connection with the killing of journalist-actvist Gauri Lankesh, was her assassin, the SIT probing the sensational case said on Friday.A senior official in the Special Investigation Team also said the same weapon was used to shoot Lankesh, and rationalists Govind Pansare and MM Kalburgi.“Waghmare shot Lankesh and the forensic report has confirmed that (rationalists) Govind Pansare, MM Kalburgi and Lankesh were murdered with the same weapon,” said a senior officer in the SIT.He, however, said the weapon was yet to be traced.Forensic examination can lead to such a conclusion when the hammer of the gun has left identical marks in the rear of a bullet, even if the weapon itself has not been found.The official said the assassin belonged to an organisation, composed of people drawn from Hindu right-wing groups, had around 60 members spread across at least five States but no name. “We discovered that this gang has a network in Madhya Pradesh, Gujarat, Maharashtra, Goa and Karnataka. We have not found their Uttar Pradesh connection so far,” the official said.He said though it recruited people from hardline Hindutva organisations such as the Maharashtra-based Hindu Jagruti Samiti and Sanatan Sanstha, these outfits may not be directly responsible for the killings.Sujith Kumar alias Praveen used to recruit people for the gang, the official said, adding that it was following his interrogation that the network was busted. The SIT, he said, suspected three more were involved in the killing of Lankesh, who was shot dead at the entrance of her Bengaluru residence on September 5 last year. A hunt is on for them. The officer said the gang meticulously planned its operations before executing them. The entire process of reconnaissance, identifying the weaknesses of the targets and their elimination would take anywhere between 6 months and a year.“The gang had almost reached the last phase of killing Prof KS Bhagawan (Kannada writer) when we nabbed them,” the officer said.The Karnataka police had uncovered the plot to kill Bhagwan recently, and it was during the interrogation of the four arrested accused that they grew suspicious about their involvement in Lankesh’s killing.The SIT had recently recovered a diary from the suspects which contained a hit-list, with high-profile names including film and theatre personality Girish Karnad,literatteur BT Lalitha Naik, rationalist CS Dwarakanath and pontiff Veerabhadra Channamalla Swamy, all of whom have been vocal in criticising the Hindu right. COMMENTS June 15, 2018 Nameless right-wing organisation has presence in five States, 60 members SHARE The SIT probing the murder of Gauri Lankesh said the organisation had a footprint in MP, Gujarat, Maharashtra, Goa and Karnataka. – PTI   –  PTI COMMENT SHARE SHARE EMAIL Published onlast_img read more

CAIT demands authority to enforce ecommerce policy

first_img COMMENT April 01, 2019 The Confederation of All India Traders (CAIT) on Sunday submitted its suggestions on the draft e-commerce policy to the Government. The traders’ body stressed on the need for a quasi-judicial or judicial body with adjudication and enforcement authority to put the policy into effect. The CAIT further reiterated its demand that the cash on delivery (CoD) mode of payment for e-commerce players must be scrapped. It further called for central registration of every e-commerce player indulging in business through any form of digital mode. “The Government is unaware about the numbers of e-commerce entities working in the country and therefore it is most necessary that a compulsory central registration system should be in place,” a press release from CAIT stated. SHARE COMMENTScenter_img Published on e commerce policy SHARE SHARE EMAILlast_img read more